Phenylallylbarbituric acid.



PATENT' OFFICE;

HEINRICH 'H6RLEIN,. 0.? VOHWINKEL, NEAR ELBERFELD, AND WALTER KROPP, OF

ELBERFELD, GERMANY, ASSIGNORS TO FARBENFABRIKEN VORM. FRIEDB. BAYER 62 (30., OFELIBERFELD, GERMANY, A CORPORATION OF GERMANY.

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1,056,793.. No Drawing.

which has proved to be a valuable hypnotic;

an average dose being from i to J; gram.

The process for its production consists m condensing phenylallylmalonic acid ester with urea in the presence of sodium alcoholate COOCzHs NH: 6 CQ-NH a +do io+2c;mos.

doocnn ts: do-im' In order to illustrate the new process more fully the following example is given, the parts bein by we1ght:276-parts of phenylallylma omc acid ester (=1 mo1.)' are added to a solution of 35 parts of sodium (:1-5 mol.) in 1200 parts of absolute alco-' hol. 90 parts .of urea (=1.5 mol.)- are added thereto and the mixtureis heated to boiling in a vessel provided with a reflux condenser during 6 hours. Subsequently the Specification of Letters Patent. Application filed-Tilly 16, 1912. Serial No. 709,691.

' Witnesses:

Patented Mar. 25, 1913.

mixture is filtered the alcohol is distilled oil in WW0, water is added to the residue and a precipitate thus obtained is filtered oil. I The liquid is neutraliz'ed with dilute hydrochloric acid.- 'iThe phenylallylbarbituric acid preci itates from the liquid.

7 Our new su stance crystallizes from water in the shape of white leaflets melting at 154-155? C.- and dissolves in alcohol. It

possesses the-property of forming salts with many metals e. gxthe' alkali metals, or the calclum, the hydrogen of the NH group be ng'replaced .by the metal. It may be 'either usedin the acid or salt form. The

sodium salt is a white'crysta'lline powder easily soluble in water. We claim:'-

As anew productphenylallylbarbiturie acid of the formula: y

96H. H a I.\C6 N:H-

crlystallizing from waterin the shapeiofw ite leaflets. melting at 154- 155"v IC-g; forming salts with alkali metals and calcium; I

and being a valuable hypnotic, substantially 'asvdescribed-A I In testimony whereof we have hereunto.

presence of two 'sub- I setour hands in the SCI'lblIlg witnesses.

HEINRICH. HoRLEIu, 1 {Li -1f -W -ALTER KROPI; 

